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A metabolomics perspective of human brain tumours |
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Attached is a review article article FEBS Journal 274 (2007) 1132-1139, A metabolomics perspective of human brain tumours Julian L. Griffin1 and Risto A. Kauppinen2 1 Department of Biochemistry, University of Cambridge, UK 2 School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, UK Abstract: During the past decade or so, a wealth of information about metabolites in various human brain tumour preparations (cultured cells, tissue specimens, tumours in vivo) has been accumulated by global profiling tools. Such holistic approaches to cellular biochemistry have been termed metabolomics. Inherent and specific metabolic profiles of major brain tumour cell types, as determined by PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (H-1 MRS), HAVE ALSO BEEN USED TO DEFINE METABOLITE PHENOTYPES IN TUMOURS IN VIVO. This minireview examines the recent advances in the field of human brain tumour metabolomics research, including advances in MRS and mass spectrometry technologies, and data analysis.
The full text is in griffin07.pdf. |