Marie-Curie Fellow
Research & Training Network
A. Wright (ER)

Marie Curie Fellow (ER) of the FAST project
Radboud University Nijmegen Medical Centre, Netherlands
Contact

• T6 Applications
  Task 6 judges and criticizes/approves FAST's innovations in preclinical and clinical settings. T6 also improves knowledge about diseases and metabolomics, gathered through MRSI. In essence, metabolomics pertains to identification of as many metabolites as possible and to understand each in its own biochemical context. MRSI can measure metabolite concentrations, chemical shifts, pH, etc. non-invasively and therefore has a huge potential for this task. Through time, much more emphasis will be placed on diagnosing and treating symptoms before secondary symptoms occur -- prevention rather than the cure of a (potential) disease. The role of Industrial partner Sanofi-Aventis is important in this task.

My research is focused on improving the quality of clinical information that can be obtained from MRSI data, in particular from prostate cancer patients. Providing an automated analysis of these MRSI data sets, requiring a minimum of specialist knowledge, is necessary if the technique is to be used routinely in the clinic.

My work has three main areas

1. Automated quality control protocols for identifying voxels in an MRSI dataset that have suitable spectral quality to provide clinically useful information.

2. Peak alignment of prostate cancer MRSI datasets for improved metabolite quantitation

3. Removal of contaminating lipid signals from prostate MRSI datasets.