Peer-reviewed Journal Articles

2009

• C.Cudalbu, V. Mlynárik, L. Xin and R. Gruetter, "Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4T and 14.1T", Magn. Reson. Med. - accepted

• J. P. Marques, R. Maddage, V. Mlynárik, R. Gruetter, "On the origin of the MR image phase contrast: An in vivo MR microscopy study of the rat brain at 14.1T.", NeuroImage - accepted

• B. Mortamet, M.A. Bernstein, C.R. Jack Jr, J.L. Gunter, C. Ward, P.J. Britson, R. Meuli, J.P. Thiran, G. Krueger and the Alzheimer's Disease Neuroimaging Initiative,"Automatic quality assessment in structural brain magnetic resonance imaging", Magn. Reson. Med. - in press

• R. B. van Heeswijk, K. Uffmann, A. Comment, F. Kurdzesau, C. Perazzolo, C. Cudalbu, S. Jannin, J. A. Konter, P. Hautle, B. van den Brandt, G. Navon, J. J. van der Klink and R. Gruetter, "Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents", Magn. Reson. Med. - accepted

• W. van der Zwaag, J. P. Marques, M. Hergt, R. Gruetter, "Investigation of high resolution fMRI by means of surface and array RF-coils at 7T.", Journal of Magnetic Resonance Imaging - accepted

• C. Poitry-Yamate, H. Lei, R. Gruetter, "The rate-limiting step for glucose transport into the hypothalamus is across the blood-hypothalamus interface", Journal of Neurochemistry - accepted

• H. Lei, C. Berthet, L. Hirt, R. Gruetter, "Evolution of the neurochemical profile following transient focal cerebral ischemia in the mouse brain", Journal of Cerebral Blood Flow and Metabolism - accepted

• L. Xin, H. Frenkel, V. Mlynárik, F. D. Morgenthaler, R. Gruetter, "Selective resonance suppression ¹H-[¹³C] NMR spectroscopy with asymmetric adiabatic RF pulses", Magn. Reson. Med. - accepted

• R. Mekle, V. Mlynárik, G. Gambarota, M. Hergt, G. Krueger, R. Gruetter, "MR spectroscopy of the human brain with enhanced signal intensity at ultra-short echo times on a clinical platform at 3 T and 7 T", Magn. Reson. Med. - accepted

• G. Gambarota, R. Mekle, L. Xin, M. Hergt, W. van der Zwaag, G. Krueger and R. Gruetter, "In vivo measurement of glycine with short echo-time ¹H MRS in human brain at 7 T", Magn. Reson. Mater. Phy. 22(1):1-4 (2009) - [Epub 2008 Oct 24.]
  
   

2008

• G. Gambarota, R. Mekle, V. Mlynárik, G. Krueger, "NMR Properties of Human Median Nerve at 3 Tesla: Proton Density, T1, T2 and Magnetization Transfer", JMRI 2008 - accepted

• A. Comment, J. Rentsch, F. Kurdzesau, S. Jannin, K. Uffmann, R.B. van Heeswijk, P. Hautle, J.A. Konter, B. van den Brandt, R. Gruetter, and J.J. van der Klink, "Producing over 100ml of highly concentrated hyperpolarized solution by means of dissolution DNP", J. Magn. Reson. - 194(1):192-195 (2008)

• A. Comment, B. van den Brandt, J. A. Konter, P. Hautle, F. Kurdzesau, S. Jannin, K. Uffmann, W. Th. Wenckebach, R. Gruetter, J. J. van der Klink, "Principles of operation of a DNP hyperpolariser coupled to a rodent MRI scanner", Applied Magn. Reson., 34, 313 (2008)

• C. Cudalbu, V. Mlynárik, L. Xin and R. Gruetter, "Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE ¹H MRS spectra", IST 2008 - IEEE Workshop on Imaging Systems and Techniques Proceedings, art. no. 4659991, pp. 311-314

• V. Mlynárik, C. Cudalbu, L. Xin and R. Gruetter, "¹H NMR spectroscopy of rat brain in vivo at 14.1 Tesa: Improvements in quantification of the neurochemical profile", J. Magn. Reson. 194(2):163-168 (2008)

• R. Mekle, W. van der Zwaag, A. Joosten, and R. Gruetter, "Comparison of three commercially available radio frequency coils for human brain imaging at 3 Tesla", Magn. Reson. Mater. Phy. 21(1-2):53-61 (2008)

• V. Mlynárik, I. Kohler, G. Gambarota, A. Vaslin, P. Clarke and R. Gruetter, "Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times.", Magn. Reson. Med. 59(1):52-58 (2008)

• L. Xin, G. Gambarota, V. Mlynárik and R. Gruetter, "Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T", NMR Biomed. 21:396-401 (2008)

• H. Lei, V. Mlynárik, N. Just and R. Gruetter, "Snapshot gradient-recalled echo-planar images of rat brains at long echo time at 9.4 T.", Magn. Reson. Imaging26(7):954-960 (2008)

• G. Gambarota, L. Xin, C. Perazzolo, I. Kohler, V. Mlynárik and R. Gruetter, "In Vivo ¹H NMR measurement of glycine in rat brain at 9.4 T at short echo time.", Magn. Reson. Med. - 60(3):727-731 (2008)

• F. Morgenthaler, R. B. van Heeswijk, L. Xin, S. Laus, H. Frenkel, H. Lei and R. Gruetter, "Non-invasive quantification of brain glycogen absolute concentration.", J. Neurochem. 107(5):1414-23 (2008)

2007

• K. Uffmann and R. Gruetter, "Mathematical Modeling of ¹³C label incorporation of the TCA cycle: the concept of composite precursor functions", Special Issue of Journal of Neuroscience Research , J Neurosci Res. 85(15):3304-3317 (2007)

• R. B. van Heeswijk, S. Laus, F. D. Morgenthaler and R. Gruetter, "Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions.", Magn. Reson. Imag. 25:821-825 (2007)

• H. Lei, F.D. Morgenthaler, T. Yue and R. Gruetter, "Direct validation of in vivo localized ¹³C MRS measurements of brain glycogen.", Magn. Reson. Med. 57:243-248 (2007)

• Comment A, van den Brandt B, Uffmann K, Kurdzesau F, Jannin S, Konter JA, Hautle P, Wenckebach WTh, Gruetter R, van der Klink JJ, "Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner.", Concepts Magn Reson B: MR Engineering 31B(4):255-269 (2007)

Conference abstracts

2009

XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function & IXth International Conference on Quantification of Brain Function with PET (Chicago, IL USA, June 29-July 3)

• C. Cudalbu, B. Lanz, F. Morgenthaler, Y. Pilloud, V. Mlynarik, R. Gruetter, Poster, "Glutamine Synthesis Rate in the hyperammonaemic rat brain using simultaneous localized in vivo 1H and 15N MRS ", XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function & IXth International Conference on Quantification of Brain Function with PET, Chicago, IL USA, June 29-July 3, 200.

2008

ISMRM : International Society for Magnetic Resonance in Medicine (May 3-9, Toronto)

• Y. van de Looij, A. Chatagner, N. Kunz, P. S. Hüppi, S.V. Sizonenko and R. Gruetter, "Magnetic Resonance Spectroscopy and Imaging at 9.4T in P4 Rat Pup Brain Following Cerebral Hypoxia-Ischemia."
  

• R. Mekle, G. Gambarota, V. Mlynarik, and R. Gruetter, "Improved Spectral Quality Through Enhanced Shimming on a Clinical Platform at 3T and 7T."

• R. Mekle, V. Mlynarik, G. Gambarota, M. Hergt, G. Krueger, and R. Gruetter, "High-Quality MR Spectroscopy of the Human Brain with Full Signal Intensity at Echo Times Below 6 ms on a Clinical Platform at 3T and 7T."

• T. Kober, W. van der Zwaag, J. Marques, R. Meuli, R. Gruetter, and G. Krueger, "Adaptive FID-navigators for respiration monitoring in multi-slice fMRI applications."

• V. Mlynarik, C. Cudalbu, L. Xin, and R. Gruetter, "Improved spectral dispersion in proton MR spectroscopy of the neurochemical profile in the rat brain at 14.1 Tesla."

• C. Cudalbu, V. Mlynarik, L. Xin, and R. Gruetter, "Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE ¹H MRS spectra at 14.1 T."

• C. Cudalbu, V. Mlynarik, L. Xin, and R. Gruetter, "¹H NMR T₁ relaxation times of the neurochemical profiles in rat brain at 14.1T."

• C. Cudalbu, A. Comment, K. Uffmann, R. B. van Heeswijk, C. Perazzolo, F. Kurdzesau, S. Jannin, V. Denisov, D. Kirik, J. J. van der Klink, and R. Gruetter, "In vivo detection of hyperpolarized 15N Choline in the rat."

• G. Gambarota, R. Mekle, L. Xin, M. Hergt, W. Van der Zwaag, and R. Gruetter, "In Vivo ¹H NMR measurement of glycine in human brain at 7 T at short echo time."

• G. Gambarota, R. Mekle, and R. Gruetter, "High-Resolution MR Imaging of the Foot: Magnetization Transfer Effects in Foot Peripheral Nerves."

• G. Gambarota, R. Mekle, and R. Gruetter, "Magnetization transfer effects in human median nerve at 3 T."

• H. Lei, C. Berthet, L. Hirt and R. Gruetter, "MRI/MRS of ischemic evolution in mouse brain at 14.1T."

• J. P. Marques, C. Cudalbu, C. Poitry-Yamate, V. Mlynarik, and R. Gruetter, "Phase Imaging of the in vivo Rat brain at 14.1 Tesla."

• J. P. Marques, T. Kober, W. van der Zwaag, G. Krueger and R. Gruetter, "MP2RAGE, a self-bias field corrected sequence for improved segmentation at high field."

• N. Just, H. Frenkel, S.Germain, R. Gruetter, "Bold fMRI investigation of the trigeminal nerve stimulation at 9.4T."

• Uffmann K, Comment A, van Heeswijk RB, Perazolla C, Jannin S, Kurdzesau F, Konter JA, Hautle PA, van der Brandt B, van der Klink JJ, Gruetter R, "Hyperpolarized ¹³C acetate detection in the rat brain in vivo."

• W. van der Zwaag, J. Marques, T. Kober, and R. Gruetter, "A continuous Nyquist ghost correction for EPI-based fMRI."

• W. van der Zwaag, H. Lei, N. Just, J. Marques, and R. Gruetter, "Minimization of Nyquist ghosting for fMRI at ultra-high fields based on a 'negative read-out gradient' strategy."

• L. Xin, H. Frenkel, F. D. Morgenthaler, V. Mlynárik and R. Gruetter, "Localized ¹H [¹³C] NMR Measurement of N-acetyl-aspartate Turnover in Rat Brain."

• L. Xin, G. Gambarota, C. Cudalbu, V. Mlynárik and R. Gruetter, "Hahn T₂ Relaxation Times of the Neurochemical Profile at 14.1T in the in vivo Rat Brain."

• B. Lanz, K. Uffmann, M. T. Wyss, B. Weber, A. Buck and R. Gruetter, "Mathematical model of glial metabolism assessed using C1-labeled acetate."

• RB van Heeswijk, and R. Gruetter, "¹³C spectroscopic imaging of glycogen and metabolites in the rat brain."

• RB van Heeswijk, K Uffmann, A Comment, F Kurdzesau, C Perazzolo, C Cudalbu, S Jannin, T Konter, P Hautle, B van den Brandt, JJ Van der Klink, G Navon, and R Gruetter, "Detection and imaging of hyperpolarized 6-lithium in the rat brain in vivo."

2007

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ADA : American Diabetes Association (June 22-26, Chicago)

• Florence D. Morgenthaler, Sabrina Laus, Lijing Xin, Ruud Van Heeswijk, Hanne Frenkel, Hongxia Lei and Rolf Gruetter, "A Novel Approach Towards Measuring Absolute Brain Glycogen Concentration Changes in vivo"

ISMRM : International Society for Magnetic Resonance in Medicine (May 19-25, Berlin)

• G. Gambarota, L. Xin, V. Mlynárik, and R. Gruetter, "J-Coupling Effects on Signal Modulation at Very High Fields."
  

• G. Gambarota, V. Mlynárik, L. Xin, and R. Gruetter, "Magnetic field strength dependence of S-PRESS signal modulation in glutathione."

• G. Gambarota, R. Mekle, V. Mlynárik, G. Krueger and R. Gruetter "T1 and T2 relaxation times of median nerve at 3 Tesla."

• G. Gambarota, L. Xin, I. Kohler, C. Perazzolo, V. Mlynárik and R. Gruetter, "Proton NMR detection of glycine in rat brain at 9.4 T."

• N.Just, N.Kunz, I.Kohler, P.Hüppi, S.Sizonenko and R. Gruetter, " Investigation of metabolite changes in neonatal rat brain after cerebral hypoxia-ischemia using 1H-spectroscopy at 9.4T."

• N.Just, N.Kunz, R.Charrier, H.Lei, M.Bach Cuadra, R.Gruetter and JP Thiran, " Bias Field Correction of surface coil MR images of rodent brain acquired at high field."

• N. Kunz, E. J. Camm, I. Kohler, S. V. Sizonenko, M. L. Aubert, R. Gruetter, and P. S. Hüppi, " Effects of fetal Nicotine, Dexamethasone exposure and caloric restriction on the neurochemical profile of the postnatal rat."

• R. Mekle, V. Mlynarik, G. Gambarota, and R. Gruetter,"Full Signal Intensity for Short Echo Time Localized Spectroscopy on a Clinical Scanner."

• F. D. Morgenthaler, S. Laus, H. Frenkel, L. Xin, R. B. van Heeswijk, H. Lei and R. Gruetter, "In vivo measurement of ¹³C Isotopic Enrichment of brain glycogen. Effect of adrenergic stimulation on glycogen turnover."

• K. Uffmann and R. Gruetter, " Towards a clinically feasible measurement of TCA cycle rates: a novel approach for mathematical modeling."

• L. Xin, G. Gambarota, V. Mlynárik, I. Kohler and R. Gruetter, "T2 relaxation of coupled spin resonances of cerebral metabolites in rat brain at 9.4 T."

• L. Xin, V. Mlynárik, H. Frenkel, and R. Gruetter, "¹³C-edited 1H NMR Spectroscopy with Selective Resonance Suppression Using Asymmetric Adiabatic RF Pulses."

• V. Mlynárik, I. Kohler, F. Frigerio, P. Maechler, and R. Gruetter, "Short-echo-time ¹H MRS of the mouse lacking brain-specific glutamate-dehydrogenase."

• V. Mlynárik, G. Gambarota, I. Kohler and R. Gruetter, "Short-TE proton spectroscopic imaging of the neurochemical profile in the rat brain at 1 μl resolution."

• V. Mlynárik, G. Gambarota, L. Xin and R. Gruetter, "Precision of metabolite concentrations obtained by LCModel as a function of the signal-to-noise ratio in rodent brain."

• RB van Heeswijk, K Uffmann, F Kurdzesau, S Jannin, A Comment, T Konter, P Hautle, B van den Brandt, JJ van der Klink, G Navon and R. Gruetter, "Towards Detection of Sub-Micromolar Contrast Agent Concentration with Hyperpolarized 6-Lithium."

• A vom Endt, J Riegler, E Eberlein, F Schmitt, U Dorbert, G Krüger and Rolf Gruetter, "High-Performance Head Gradient Coil for 7T Systems."

• B van den Brandt, A Comment, J. A. Konter, P Hautle, F Kurdzesau, S Jannin, R Gruetter, W Th Wenckebach and JJ. van der Klink, "A Dynamic Nuclear Polarisation System Based on a Continuous-Flow 4He Cryostat."

• Comment A, Uffmann K, Jannin S, Kurdzesau F, van Heeswijk RB, Frenkel H, Hautle P, Konter JA, van den Brandt B, Gruetter R and van der Klink JJ, "In Vivo DNP-Enhanced 13C Labeled Acetate Brain Studies in a 9.4T Animal Scanner."

Symposium : Limiting Hypoglycemia : The challenge of intensive treatment of diabetes melitus (May 12-15, Perugia)

• C.L. Poitry-Yamate, H. Frenkel, H. Lei and R. Gruetter, "Glucose and glycogen content in rat hypothalamus at euglycemia and hypoglycemia "